000			04140namaa2200493uu 4500
001			oapen87680
003			oapen
005			20240507100420.0
006			m o d
007			cr|mn|---annan
008			240214s2018 xx |||||o ||| 0|eng d
020			_a9780367656997
020			_a9780815365327
020			_a9781351261760
020			_a9781351261760
024	7		_a10.1201/9781351261760 _2doi
040			_aoapen _coapen
041	0		_aeng
042			_adc
072		7	_aMF _2bicssc
072		7	_aPS _2bicssc
072		7	_aPSD _2bicssc
072		7	_aPSF _2bicssc
100	1		_aFlohé, Leopold _4edt
245	1	0	_aGlutathione
260			_bTaylor & Francis _c2018
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aOxidative Stress and Disease
506	0		_aFree-to-read _fUnrestricted online access _2star
520			_aThis is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione--transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery
540			_aAll rights reserved _uhttp://oapen.org/content/about-rights
546			_aEnglish
650		7	_aBiology, life sciences _2bicssc
650		7	_aCellular biology (cytology) _2bicssc
650		7	_aMolecular biology _2bicssc
650		7	_aPre-clinical medicine: basic sciences _2bicssc
653			_aProtein Tyrosine Phosphatase 1B,LMW Thiol,GPx4 Expression,Active Site Cysteine,GPx1 mRNA,Thiol Disulfide Exchange Reactions,FeS Clusters,GCL Activity,GPx1 KO,GPx1 Activity,Mixed Disulfide,Iron Sulfur Clusters,Labile Iron Pool,Thiol Disulfide Oxidoreductases,GCLC Expression,Total GSH Content,GSH Transport,GSH Synthesis,BLM.,Iron Dependent Lipid Peroxidation,Mitochondrial GSH,Renal Proximal Tubular Cells,Free GSH,Dual Specificity Protein Phosphatase,PT,Biosynthesis,Adaptive Stress Response,Detoxification,Redox Reactions,Drug Discovery,Henry J. Forman,Hongqiao Zhang,Terrance J. Kavanagh,Lawrence H. Lash,Laura Orian,Giorgio Cozza,Matilde Maiorino,Stefano Toppo,Fulvio Ursini,Diane E. Handy,Joseph Loscalzo,Holger Steinbrenner,Lars-Oliver Klotz,Anna P. Kipp,Antonella Roveri,José Pedro,Friedmann Angeli,Valerian E. Kagan,Marcus Conrad,Yefim Manevich,Lutz Schomburg,Bengt Mannervik,Birgitta Sjödin,Kenneth D. Tew,Ralf Morgenstern,Jesper Z. Haeggström,Per-Johan Jakobsson,Leopold Flohé,Iain L. O. Buxton,Scott D. Barnett,Linda Liedgens,Marcel Deponte,Carsten Berndt,Anna Dorothee Engelke,Klaudia Lepka,Lars Bräutigam,Marcelo A. Comini,Martin Hugo,Madia Trujillo,Lucía Piacenza,Rafael Radi,Leonardo Astolfi Rosado,BrandPedre,Joris Messens,Quach Ngoc Tung,Nico Linzner,Vu Van Loi,Haike Antelmann
700	1		_aFlohé, Leopold _4oth
793	0		_aOAPEN Library.
856	4	0	_uhttps://library.oapen.org/handle/20.500.12657/87680 _70 _zFree-to-read: OAPEN Library: description of the publication
999			_c37156 _d37156