Proteostasis and Proteolysis

By:

Chondrogianni, Niki [edt]

Contributor(s):

Material type: Text

TextLanguage: English Publication details: Taylor & Francis 2022Description: 1 online resourceContent type:

text

Media type:

computer

Carrier type:

online resource

ISBN:

9780367499327
9780367499334
9781003048138
9781003048138

Subject(s):

Biology, life sciences
Molecular biology
Organic chemistry
Pre-clinical medicine: basic sciences
ad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process, Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues, response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded

Online resources:

Free-to-read: OAPEN Library: description of the publication

Summary: Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies.

Tags from this library: No tags from this library for this title. Log in to add tags.

Average rating: 0.0 (0 votes)

No physical items for this record

Free-to-read Unrestricted online access star

Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies.

http://oapen.org/content/about-rights

English

There are no comments on this title.

to post a comment.